脳神経外科医亦野文宏(またのふみひろ)

研究業績

代表的な論文の紹介

手術後の「髄液漏れ」を防ぐために/前頭洞を安全に閉鎖する脳神経外科の工夫

脳動脈瘤や前頭蓋底腫瘍の手術では、両側前頭開頭という方法を用いることがあります。

この手術では、額の奥にある「前頭洞」という空洞が開放されることがあります。前頭洞は鼻の中とつながっているため、閉鎖が不十分だと、術後に髄液が鼻から漏れる「髄液鼻漏」や髄膜炎の原因になることがあります。私たちは、前頭洞の粘膜を丁寧に剥離し、6-0ナイロン糸で直接縫合して閉鎖する方法を行っています。さらにフィブリン糊をしみ込ませた素材で補強し、自家骨で保護することで、より確実な閉鎖を目指しています。

本研究では、前大脳動脈瘤に対して両側前頭開頭を行い、前頭洞が開放された34例を対象に、この方法の長期成績を検討しました。その結果、長期経過において髄液鼻漏や髄膜炎などの重篤な合併症を認めず、本手技の有用性が示されました。見えない部分の丁寧な処置こそが、安全な脳神経外科手術を支えています。

【論文】
Matano F, Nounaka Y, Murai Y. (2025) Frontal sinus mucosa suture closure technique for prevention of cerebrospinal fluid rhinorrhea after bifrontal craniotomy: long-term follow-up results. Neurosurg Focus. 58(2): E10.

脳の血圧を直接測る / バイパス手術をより安全にするための挑戦

脳梗塞の危険が高い患者さんに対して行われるSTA-MCAバイパス術では、血管がつながったことは確認できても、「脳にどれくらい血液が届いているか」を直接評価する方法はありませんでした。私たちは上山博康先生が考案された、手術中に脳の血圧（中大脳動脈圧）を直接測定する方法を学びそのデータを詳細に調べました。その結果、術中の脳圧は術前SPECTで評価した脳血流とよく相関し、術後の過灌流症候群の予測にも有用であることを明らかにしました。脳循環を「見える化」することで、より安全で精度の高い脳血行再建術を目指しています。

【論文】
Matano F, Murai Y, Tanikawa R, Kamiyama H, Tateyama K, Tamaki T, Mizunari T, Mizumura S, Kobayashi S, Teramoto A, Morita A. (2016) Intraoperative middle cerebral artery pressure measurements during superficial temporal artery to middle cerebral artery bypass procedures in patients with cerebral atherosclerotic disease. J Neurosurg. 125(6):1367-1373.

原著論文

  1. Matano F, Murai Y, Mizunari T, Ideguchi M, Koketsu K, Sasaki T, Nishi T, Yamashiro S, Date I, Hishikawa T, Ikawa F, Sakamoto S, Takizawa K, Kobayashi T, Mori K, Moroi J, Osato T, Suzuki M, Hadeishi H, Shiokawa Y, Saito A, Uno M, Sora S, Kawashima A, Mizutani T, Tamaki T, Tanikawa R, Morita A. (2026) Frailty and Severe White Matter Lesions Are Risk Factors for Surgical Treatment for Unruptured Cerebral Aneurysm in Older Adults. Neurol Med Chir (Tokyo). May 15.
  2. Matano F, Nounaka Y, Murai Y. (2025) Frontal sinus mucosa suture closure technique for prevention of cerebrospinal fluid rhinorrhea after bifrontal craniotomy: long-term follow-up results. Neurosurg Focus. 58(2): E10.
  3. Nounaka Y, Matano F, Umeoka K, Kubota A, Matsumoto N, Higuchi T, Umezawa H, Matsunobu T, Kitamura T, Igarashi Y, Nakae R, Yokobori S, Murai Y. (2025) Head Mounted Three-Dimensional High-Definition Display System for Microscopic Surgical Field Observation: An Observational Study. World Neurosurg. 201:123256.
  4. Hagiwara M, Maeda-Minami A, Matano F, Nounaka Y, Murai Y, Morita A, Mano Y. (2025) Association Between Statin Use and Risk of Subarachnoid Hemorrhage: A Case- Control Study Using Large-Scale Claims Data. Stroke. 56(9): 2597-2604.
  5. Nounaka Y, Shirokane K, Matano F, Koketsu K, Kubota A, Morita A, Murai Y. (2024) The Second-Set Surgeries for Multiple Unruptured Aneurysms Do Not Increase Perioperative Complications. Neurosurg Pract. 5(3): e00037.
  6. Matano F, Tahara S, Hattori Y, Nounaka Y, Isayama K, Teramoto A, Morita A. (2024) Wrapping method for better fat handling in endoscopic trans-sphenoidal surgery. Surg Neurol Int. 15:390.
  7. Murai Y, Matano F, Kubota A, Nounaka Y, Ishisaka E, Shirokane K, Koketsu K, Nakae R, Tamaki T. (2024) RNF213-Related Vasculopathy: Various Systemic Vascular Diseases Involving RNF213 Gene Mutations: Review. J Nippon Med Sch. 92. 140-145.
  8. Nounaka Y, Murai Y, Kubota A, Tsukiyama A, Matano F, Koketsu K, Morita A. (2024) Pathological Findings of Doner Vessels in Bypass Surgery. J Clin Med. 13. 2125.
  9. Matano F, Murai Y, Nounaka Y, Higuchi T, Mihara R, Isayama K, Morita A. (2024) Experience Using Gentian Violet-Free Dyes for Tissue Visualization. J Neurol Surg A Cent Eur Neurosurg. 85(2).526-530.
  10. Camara B, Fava A, Matano F, Okano A, Ronconi D, Silva Costa B, Gadelha Figueriedo E, Chassoux F, Devaux B, Froelich S. (2023) Transuncal Selective Amygdalohipocampectomy by an Inferolateral Preseptal Endoscopic Approach Through Inferior Eyelid Conjuctical Incision: An Anatomic Study. Oper Neurosurg (Hagerstown). 25(2): 199-208.
  11. Matano F, Passeri T, Abbritti R, Camara B, Mastantuoni C, Noya C, Giammattei L, Devaux B, Mandonnet E, Froelich S. (2022) Eyebrow incision with a crescent-shaped orbital rim craniotomy for microscope and endoscope transorbital approach to the anterior and middle cranial fossa: A cadaveric study and case presentation. Brain Spine. 28 (2):100891.
  12. Murai Y, Matano F, Isayama K, Nounaka Y, Morita A. (2022) Evaluation of Ethyl Violet as an Alternative Dye to Crystal Violet to Visualize the Vessel Wall during Vascular Anastomosis. Neuro Med Chir (Tokyo). 62(11): 530-534.
  13. Matano F, Mizunari T, Murai Y, Tamaki T, Tateyama K, Suzuki M, Morita A. (2022)
    White Matter Lesions as Brain Frailty and Age are Risk Factors for Surgical Clipping of Unruptured Intracranial Aneurysms in the Elderly. J Stroke Cerebrovasc Dis. 29(10):105121.
  14. Giammattei L, Passeri T, Abbritti R, Lieber S, Matano F, Le Van T, Okano A, Fava A, di Russo P, Froelich S. (2022) Surgical morbidity of the extradural anterior petrosal approach: the Lariboisiere experience. J Neurousurg. 138(1): 276-286.
  15. Murai Y, Shirokane K, Sato S, Higuchi T, Kubota A, Ozeki T, Matano F, Sasakai K, Yamaguchi F, Morita A. (2022) Preliminary Clinical Surgical Experience with Temporary Simultaneous Use of an Endoscope during Exoscopic Neurosurgery: An Observation Study. J Clin Med. 11(7): 1753.
  16. Fava A, di Russo P, Passeri T, Camara B, Paglia F, Matano F, Okano A, Giammattei L, Froelich S. (2022) The mini-combined transpetrosal approach: an anatomical study and comparison with the combined transpetrosal approach. Acta Neurochir (Wien). 164 (4):1079-1093.
  17. Murai Y, Ishisaka E, Tsukiyama A, Kubota A, Yamaguchi M, Matano F, Tamaki T, Mizunari T, Morita A. (2022) Contest-style evaluation for the objective assessment of microsurgical techniques: an observational study. J Nippon Med Sch. Jan 25.
  18. Murai Y, Sekine T, Ishisaka E, Tsukiyama A, Kubota A, Matano F, Ando T, Nakae R, Morita A. (2022) Factors Influencing Long-Term Blood Flow in Extracranial-to-Intracranial Bypass for Symptomatic Internal Carotid Artery Occlusive Disease: A Quantitative Study. Neurosurgery 1;90(4):426-433.
  19. Ishizawa T, McCulloch P, Muehrcke D, Carus T, Wiesel O, Dapri G, Schneider-Koriath S, Wexner SD, Abu-Gazala M, Boni L, Cassinotti E, Sabbagh C, Cahill R, Ris F, Carvello M, Spinelli A, Vibert E, Terasawa M, Takao M, Hasegawa K, Schols RM, Pruimboom T, Murai Y, Matano F, Bouvet M, Diana M, Kokudo N, Dip F, White K, Rosenthal RJ. (2021) Assessing the development status of intraoperative fluorescence imaging for perfusion assessments, using the IDEAL framework. BMJ Surg Interv Health Technol. 19;3(1):e000088.
  20. Murai Y, Ishisaka E, Watanabe A, Sekine T, Shirokane K, Matano F, Nakae R, Tamaki T, Koketsu K, Morita A. (2021) Ring finger protein 213 c.14576G>A mutation is not involved in internal carotid artery and middle cerebral artery dysplasia. Sci Rep. 12;11(1):22163. 
  21. Murai Y, Ishisaka E, Watanabe A, Sekine T, Shirokane K, Matano F, Nakae R, Tamaki T, Koketsu K, Morita A. (2021) RNF213 c.14576G>A Is Associated with Intracranial Internal Carotid Artery Saccular Aneurysms. Genes (Basel).23;12(10):1468.
  22. Ishisaka E, Watanabe A, Murai Y, Shirokane K, Matano F, Tsukiyama A, Baba E, Nakagawa S, Tamaki T, Mizunari T, Tanikawa R, Morita A. (2021) Role of RNF213 polymorphism in defining quasi-moyamoya disease and definitive moyamoya disease. Neurosurg Focus. 51(3):E2.
  23. Sekine T, Murai Y, Orita E, Ando T, Takagi R, Amano Y, Matano F, Iwata K, Ogawa M, Obara M, Kumita S. (2021) Cross-Comparison of 4-Dimensional Flow Magnetic Resonance Imaging and Intraoperative Middle Cerebral Artery Pressure Measurements Before and After Superficial Temporal Artery-Middle Cerebral Artery Bypass Surgery. Neurosurgery. 13;89(5):909-916.
  24. Murai Y, Matano F, Shirokane K, Tateyama K, Koketsu K, Nakae R, Sekine T, Mizunari T, Morita A. (2021) Lesion Trapping with High-Flow Bypass for Ruptured Internal Carotid Artery Blood Blister-Like Aneurysm Has Little Impact on the Anterior Choroidal Artery Flow: Case Series and Literature Review. World Neurosurg. 153:e226-e236.
  25. Shibata A, Matano F, Saito N, Fujiki Y, Matsumoto H, Mizunari T, Morita A. (2021)
    Serum Glucose-To-Potassium Ratio as a Prognostic Predictor for Severe Traumatic Brain Injury. J Nippon Med Sch. 1;88(4):342-346.
  26. Murai Y, Shirokane K, Kitamura T, Tateyama K, Matano F, Mizunari T, Morita A. (2020) Petrous Internal Carotid Artery Aneurysm: A Systematic Review. J Nippon Med Sch. 9;87(4):172-183.
  27. Hironaka K, Aso S, Suzuki M, Matano F, Matsui H, Fushimi K, Yasunaga H, Morita A. (2020) Outcomes in Elderly Japanese Patients Treated for Aneurysmal Subarachnoid Hemorrhage: A Retrospective Nationwide Study. J Stroke Cerebrovasc Dis. 29(6):104795.
  28. Matano F, Murai Y, Sato S, Koketsu K, Shirokane K, Ishisaka E, Tsukiyama A, Morita A. (2020) Risk factors for ischemic complications in vascular reconstructive surgeries. Clin Neurol Neurosurg 193:105768.
  29. Murai Y, Matano F, Morita A. (2020) MRI Punctate Sign and CTA Spot Sign for Primary Intracerebral Hemorrhage. Neurologist. 25(1):17.
  30. Ikawa F, Michihata N, Akiyama Y, Iihara K, Matano F, Morita A, Kato Y, Iida K, Kurisu K, Fushimi K, Yasunaga H. (2019) Treatment Risk for Elderly Patients with Unruptured Cerebral Aneurysm from a Nationwide Database in Japan. World Neurosurg. 132: e89-e98.
  31. Tomonori T, Fumihiro M, Michio Y, Akio M. (2019) Prevention of Back Bleeding During Carotid Endarterectomy: Analysis of Clamping Techniques. World Neurosurg.131:e186-e191.
  32. Matano F, Murai Y, Mizunari T, Yamaguchi M, Yamada T, Baba E, Shibata A, Tamaki T, Morita A. (2019) Incision of the anterior petroclinoidal fold during clipping for securing the proximal space of an internal carotid artery-posterior communicating artery aneurysm: a technical note. Neurosurg Rev. 42(3):777-781.
  33. Matano F, Fujiki Y, Mizunari T, Koketsu K, Tamaki T, Murai Y, Yokota H, Morita A.  (2019) Serum Glucose and Potassium Ratio as Risk Factors for Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage. J Stroke Cerebrovasc Dis. 28(7):1951-1957.
  34. Shibata A, Matano F, Fujiki Y, Mizunari T, Murai Y, Yokota H, Morita A. (2019)
    Efficacy of Thyrotropin-Releasing Hormone Analog for Protracted Disturbance of Consciousness due to Aneurysmal Subarachnoid Hemorrhage. J Stroke Cerebrovasc Dis. 28(4):988-993.
  35. Nakagawa S, Murai Y, Matano F, Ishisaka E, Morita A. (2018) Evaluation of Patency After Vascular Anastomosis Using Quantitative Evaluation of Visualization Time in Indocyanine Green Video Angiography. World Neurosurg. 110:e699-e709.
  36. Tsukiyama A, Murai Y, Matano F, Shirokane K, Morita A. (2018) Optical effects on the surrounding structure during quantitative analysis using indocyanine green videoangiography: A phantom vessel study. J Biophotonics. 11(4):e201700254.
  37. Fujiki Y, Matano F, Mizunari T, Murai Y, Tateyama K, Koketsu K, Kubota A, Kobayashi S, Yokota H, Morita A. (2018) Serum glucose/potassium ratio as a clinical risk factor for aneurysmal subarachnoid hemorrhage. J Neurosurg. 129(4):870-875.
  38. Matano F, Mizunari T, Murai Y, Kubota A, Fujiki Y, Kobayashi S, Morita A. (2017)
    Quantitative Comparison of the Intraoperative Utility of Indocyanine Green and Fluorescein Videoangiographies in Cerebrovascular Surgery. Oper Neurosurg (Hagerstown). 1;13(3):361-366.
  39. Murai Y, Ishisaka E, Tsukiyama A, Nakagawa S, Matano F, Tateyama K, Morita A. (2017) Reuse of a Reversed “Bone Pad” to Perforate Incompletely Penetrated Burr Holes Created by Automatic-Releasing Cranial Perforators. Oper Neurosurg (Hagerstown). 1;13(3):324-328.
  40. Murai Y, Shirokane K, Kitamura T, Matano F, Morita A. (2017) Aneurysm Tears Caused by an Aneurysm Clip Springing from the Clip Applier. Can J Neurol Sci. 44(3):326-328.
  41. Matano F, Mizunari T, Yamada K, Kobayashi S, Murai Y, Morita A. (2017) Environmental and Clinical Risk Factors for Delirium in a Neurosurgical Center: A Prospective Study. World Neurosurg. 103:424-430. 
  42. Matano F, Murai Y, Mizunari T, Tamaki T, Tateyama K, Koketsu K, Tanikawa R, Kamiyama H, Kobayashi S, Morita A. (2017) Recovery of Visual and Ophthalmologic Symptoms After Treating Large or Giant Internal Carotid Artery Aneurysm by High-Flow Bypass with Cervical Ligation. World Neurosurg. 98:182-188.
  43. Murai Y, Nakagawa S, Matano F, Shirokane K, Teramoto A, Morita A. (2016) The feasibility of detecting cerebral blood flow direction using the indocyanine green video angiography. Neurosurg Rev. 39(4):685-90.
  44. Matano F, Murai Y, Tanikawa R, Kamiyama H, Tateyama K, Tamaki T, Mizunari T, Mizumura S, Kobayashi S, Teramoto A, Morita A. (2016) Intraoperative middle cerebral artery pressure measurements during superficial temporal artery to middle cerebral artery bypass procedures in patients with cerebral atherosclerotic disease. J Neurosurg. 125(6):1367-1373.
  45. Matano F, Tanikawa R, Kamiyama H, Ota N, Tsuboi T, Noda K, Miyata S, Matsukawa H, Murai Y, Morita A. (2016) Surgical Treatment of 127 Paraclinoid Aneurysms with Multifarious Strategy: Factors Related with Outcome. World Neurosurg. 85:169-76.
  46. Matano F, Murai Y, Tateyama K, Tamaki T, Mizunari T, Matsukawa H, Teramoto A, Morita A. (2016) Long-term patency of superficial temporal artery to middle cerebral artery bypass for cerebral atherosclerotic disease: factors determining the bypass patent. Neurosurg Rev. 39(4):655-61. 
  47. Murai Y, Matano F, Toda S, Kobayashi S, Morita A. (2016) An Irrigation Suction System Using a Pressurized Fluid High-Flow Pump System in Comparison with a Standard Cuff Pressure System: Technical Note. J Neurol Surg A Cent Eur Neurosurg. 77(3):264-8.
  48. Matano F, Yoshida D, Ishii Y, Tahara S, Teramoto A, Morita A. (2014) Endocan, a new invasion and angiogenesis marker of pituitary adenomas. J Neurooncol. 117(3):485-91.
  49. Murai Y, Adachi K, Matano F, Takagi R, Amano Y, Kobayashi S, Kitamura T, Teramoto A. (2013) 3.0-T diffusion images after clipping of middle cerebral artery aneurysm. Turk Neurosurg. 23(6):772-7.
  50. Matano F, Murai Y, Tateyama K, Mizunari T, Umeoka K, Koketsu K, Kobayashi S, Teramoto A. (2013) Perioperative complications of superficial temporal artery to middle cerebral artery bypass for the treatment of complex middle cerebral artery aneurysms. Clin Neurol Neurosurg. 115(6):718-24.
  51. Murai Y, Adachi K, Takagi R, Koketsu K, Matano F, Teramoto A. (2011) Intraoperative Matas test using microscope-integrated intraoperative indocyanine green videoangiography with temporary unilateral occlusion of the A1 segment of the anterior cerebral artery. World Neurosurg. 76(5):477.e7-477.e10.
  52. Murai Y, Adachi K, Matano F, Tateyama K, Teramoto A. (2011) Indocyanin green videoangiography study of hemangioblastomas. Can J Neurol Sci. 38(1):41-7.

症例報告

  1. Yamamoto I, Higuchi T, Isayama K, Matano F, Nounaka Y, Ideguchi M, Nakae R,Morita A, Murai Y. (2025) Shunt related internal carotid artery dissection during carotid endarterectomy: illustrative cases. J Neurosurg Case Lessons. 22; 10(25):CASE25697.
  2. Fujita H, Matano F, Nounaka Y, Kubota A, Murai Y. (2026) Cavernous internal carotid artery aneurysm treated with superficial temporal artery-middle cerebral artery bypass and cervical internal carotid artery ligation using intraoperative middle cerebral artery pressure monitoring: illustrative case. J Neurosurg Case Lessons.
  3. Nounaka Y, Matano F, Isayama K, Tomiyama K, Inomoto C, Osamura RY, Tahada S, Murai Y. (2025) Coexistence Tumor of Craniopharyngioma and Pituitary Neuroendocrine Tumor: A Case Report and Literature Review. Cureus.17(9): e93606.
  4. Aoki T, Higuchi T, Nounaka Y, Matano F, Nakae R, Igarashi Y, Yokobori S, Murai Y. (2025) Acute epidural hematoma extending bilaterally and infratentorially: illustrative case. J Neurosurg Case Lessons. 9(12): CASE24756.
  5. Yamazaki M, Aoki T, Matano F, Murai Y. (2025) Ruptured distal anterior cerebral artery aneurysm presenting with acute subdural hematoma without subarachnoid hemorrhage. 2025(1): rjae843.
  6. Umeoka K, Matano F, Murai Y. (2024) Trigeminal Neuralgia due to Venous Compression Successfully Transposed by Suprameatal Tubercle Drilling. 91(6): 586-589.
  7. Nounaka Y, Matano F, Fujita H, Isayama K, Ideguchi M, Murai Y. (2024) Revascularization with superficial temporal artery-middle cerebral artery anastomosis in spontaneous intracranial internal carotid artery dissection: illustrative case. J Neurosurg Case Lessons. 8(21): CASE24332.
  8. Matsumoto Y, Nakae R, Matano F, Kubota A, Morita A, Murai Y, Yokobori S. (2023) A case of ruptured carotid traumatic blood blister-like aneurysm. NMC Case Rep J. 29;10:259-263.
  9. Nounaka Y, Murai Y, Shirokane K, Matano F, Koketsu K, Nakae R, Watanabe A, Mizunari T, Morita A. (2023) Spontaneous middle cerebral artery dissection: a series of six cases and literature review. Neurosurg Rev. 46(1):229.
  10. Matano F, Tamaki T, Yamazaki M, Enomoto H, Tateyama K, Mizunari T, Murai Y, Morita A. (2022) Vertebral artery V3 portion-radial artery-distal common carotid artery (V3-RA-dCCA) bypass for large basilar trunk aneurysm with bilateral proximal common carotid artery occlusion-technical note. Acta Neurochir (Wien). 164(4):1031-1035.
  11. Matano F, Murai Y, Watanabe A, Shirokane K, Igarashi T, Shimizu K, Shimada T, Morita A. (2021) Case Report: A Case of Moyamoya Syndrome Associated With Multiple Endocrine Neoplasia Type 2A. Front Endocrinol (Lausanne).11;12:703410.
  12. Matano F, Tamaki T, Yamazaki M, Enomono H, Mizunari T, Tateyama K, Murai Y, Tanikawa R, Morita A. (2021) Open surgical embolectomy for cardiogenic cerebral embolism: Technical note and its advantages. J Clin Neurosci. Jul;89:206-210.
  13. Matano F, Suzuki M, Mizunari T, Yamada T, Murai Y, Morita A. (2020) Radial Artery Graft for Giant Common Carotid Artery Pseudoaneurysm After Carotid Artery Stenting. World Neurosurg.139:401-404.
  14. Matano F, di Russo P, Okano A, Passeri T, Penet N, Fava A, Camara B, Polivka M, Giammattei L, Froelich S. (2020) Oculomotor Neurofibroma: A Different Histology Implying an Unsatisfying Clinical Outcome. World Neurosurg. 139:31-38.
  15. Kubota A, Murai Y, Umezawa H, Ishisaka E, Tsukiyama A, Nakagawa S, Matano F, Ogawa R, Morita A. (2019) Second Free Flap Surgery for Skull Base Tumors: Case Report and Literature Review. J Nippon Med Sch. 86(4):248-253.
  16. Matano F, Murai Y, Kubota A, Mizunari T, Kobayashi S, Morita A. (2017) The Ivy Sign on Fluid Attenuated Inversion Recovery Images Related to Single-Photon Emission Computed Tomography Cerebral Blood Flow in Moyamoya Disease: A Case Report. Turk Neurosurgery.29(4):598-602.
  17. Murai Y, Yamada T, Ishisaka E, Sato S, Matano F, Morita A. (2017) Bilateral suboccipital approach for a giant vertebral artery aneurysm. J Clin Neurosci. 45:315-318. 
  18. Murai Y, Matano F, Yokobori S, Onda H, Yokota H, Morita A. (2017) Treatment Strategies of Subarachnoid Hemorrhage from Bilateral Vertebral Artery Dissection: A Case Report and Literature Review Focusing on the Availability of Stent Placement. World Neurosurg. 106:1050.e11-1050.e20. 
  19. Matano F, Mizunari T, Kominami S, Suzuki M, Fujiki Y, Kubota A, Kobayashi S, Murai Y, Morita A. (2017) Retrograde suction decompression of a large internal carotid aneurysm using a balloon guide catheter combined with a blood-returning circuit and STA-MCA bypass: a technical note. Neurosurg Rev.40(2):351-355.
  20. Matano F, Murai Y, Mizunari T, Adachi K, Kobayashi S, Morita A. (2016) Intracerebral Hemorrhage Caused by Cerebral Hyperperfusion after Superficial Temporal Artery to Middle Cerebral Artery Bypass for Atherosclerotic Occlusive Cerebrovascular Disease. NMC Case Rep J.5;4(1):27-32.
  21. Kitamura T, Murai Y, Shirokane K, Matano F, Kitamura T, Morita A. (2016) An Unruptured Aneurysm Coexisting with an Infundibular Dilatation: A Case Report. J Nippon Med Sch.83(6):268-271.
  22. Matano F, Murai Y, Mizunari T, Tateyama K, Kobayashi S, Adachi K, Kamiyama H, Morita A, Teramoto A. (2016) Olfactory preservation during anterior interhemispheric approach for anterior skull base lesions: technical note. Neurosurg Rev. 39(1):63-8; discussion 69.
  23. Matano F, Mizunari T, Koketsu K, Fujiki Y, Kubota A, Kobayashi S, Murai Y, Morita A.  (2016) Protection Device Made of a Modified Syringe for Muscle Protection During Cranial Perforation: Technical Note. World Neurosurg.89:33-6.
  24. Murai Y, Ishisaka E, Tsukiyama A, Matano F, Morita A. (2015)
    Internal Carotid Artery Aneurysm Anomalously Originating from the Posterior Communicating Artery. World Neurosurg. 84(6):2078.e9-11. 
  25. Matano F, Murai Y, Nakagawa S, Wada T, Kitamura T, Teramoto A. (2015)
    Spontaneous angiographic regression of cerebral arteriovenous malformations: angiographic disappearance is not the real cure. Turk Neurosurg.25(1):168-73.
  26. Matano F, Murai Y, Nakagawa S, Kato T, Kitamura T, Sekine T, Takagi R, Teramoto A. (2014) Atypical radiological and intraoperative findings of acute cerebral hemorrhage caused by ruptured cerebral aneurysm in a patient with severe chronic anemia. J Nippon Med Sch. 81(4):264-8.
  27. Matano F, Adachi K, Murai Y, Kitamura T, Ohashi R, Teramoto A, Morita A. (2014)
    Microcystic meningioma with late-phase accumulation on thallium-201 single-photon emission computed tomography: case report. Neuro Med Chir (Tokyo)54(8):686-9.
  28. Matano F, Murai Y, Adachi K, Kitamura T, Teramoto A. (2014) Pathophysiology and management of intracranial arterial stenosis around the circle of Willis associated with hyperthyroidism: case reports and literature review. Neurosurg Rev. 37(2):347-56; discussion 356.
  29. Matano F, Murai Y, Adachi K, Koketsu K, Kitamura T, Teramoto A, Okubo S, Katayama Y, Sekine T, Takagi R, Kumita S. (2013) Reversible cerebral vasoconstriction syndrome associated with subarachnoid hemorrhage triggered by hydroxyzine pamoate. Clin Neurol Neurosurg. 115(10):2189-91.

科学研究費、助成金の受領

2022-2025年度　若手研究　(代表)

甲状腺機能障害に合併する頭蓋内血管狭窄の遺伝子変異と病態解析

2023-2024年度　AMED　臨床研究・治験推進研究事業（代表）

破裂脳動脈瘤によるくも膜下出血に対する開頭クリッピング術と並行した組織プラスミノーゲンアクチベータによる脳槽血腫除去療法の有効性と安全性に関する探索的研究のプロトコル作成

2022-2025年度　基盤研究 (C)　(分担)

脳動脈瘤の臨床表現型に着目したRNF213の網羅的解析

2020年度
日本医科大学同窓会医学研究助成金賞 (代表)

月形眼窩骨削除を併用した前および中頭蓋底への経眼窩法手術の開発

2020-2024年度
国際共同研究加速基金(国際共同研究強化(B))研究 (分担)

くも膜下出血はなぜ日本人に多いか？：脳血管障害をきたす体内細菌叢の国際間比較研究

研究活動

日本医科大学脳神経外科では、脳卒中、脳動脈瘤、もやもや病、脳腫瘍などの脳神経外科疾患を対象として、基礎研究から臨床研究まで幅広い研究活動を行っています。

脳神経外科医は日々の診療や手術を通じて多くの課題に直面します。当教室では、その課題を研究によって解決し、患者さんへ還元することを使命と考えています。特に脳血管障害領域では、脳動脈瘤やもやもや病の発症機序の解明、くも膜下出血後の予後改善、新たなバイパス手術戦略の確立などを目指した研究を積極的に進めています。

近年は、もやもや病感受性遺伝子として知られるRNF213に着目し、もやもや病のみならず脳動脈瘤やその他の血管障害との関連について研究を進めています。また、くも膜下出血後の遅発性脳虚血障害や全身炎症反応に関する研究を通じて、重症脳卒中患者の予後改善を目指しています。

さらに、手術用顕微鏡、外視鏡、ヘッドマウントディスプレイなどの先進的な手術支援機器を用いた研究にも取り組み、安全性と術者の操作性向上を両立する次世代脳神経外科手術の開発を進めています。

これらの研究は、文部科学省科学研究費助成事業（科研費）をはじめとする競争的研究資金の支援を受けて実施されており、国内外の研究機関との共同研究を通じて推進されています。研究成果は国際学会や査読付き学術雑誌で積極的に発表し、基礎研究から臨床応用までをつなぐトランスレーショナルリサーチを実践しています。

今後も、世界水準の研究成果を創出するとともに、その成果を患者さんに還元することで、脳神経外科医療の発展と社会への貢献を目指してまいります。